How does the hypothalamic-pituitary-adrenal axis (HPA) system contribute to the use of cannabis the development of a cannabis use disorder and the relapse to cannabis use? The HPA axis is an important hormonal response system to stress. The actions of this hormone system normally are regulated to ensure that the body can respond quickly to stressful events and return to a normal state. The main determinants of HPA axis activity are genetic background early-life environment and current life stress. According to the National Institute on Drug Abuse (NIDA) marijuana use among high schoolers is at an all-time high. In 2018 43.6% 12th graders reported that they have tried marijuana. This percentage appears to be increasing; however the number of young people who believe regular marijuana use is risky is decreasing. As of October 2019 a total of 33 states District of Columbia Guam Puerto Rico and U.S. Virgin Islands have approved a comprehensive publicly available medical marijuana programs. However only 2.5% the population uses medical marijuana. Cannabis is widely available in the United States and use is becoming culturally acceptable (123). Additionally THC concentration has increased dramatically over the last 10 years from 8.9 0n 2008 to 17.1 0n 2017 (4). The mean THC:CBD ratio also rose substantially from 23 in 2008 to 104 in 2017.Therefore it is more relevant now than ever before to determine the effects of marijuana on the brain.



Eligible Ages
Between 18 and 70
Eligible Genders
Accepts Healthy Volunteers

Study Design

early Phase 1
Study Type

More Details

Rockefeller University

Study Contact

Recruitment Office


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