Assessing Adipose Tissue and Metabolic Profiles of Childhood Cancer Survivors after Radiation Therapy: A Pilot Study
Purpose
Due to advances in multimodality therapy 5-year survival rates for childhood cancer now exceed 80%. Survivors however face an increased lifelong risk of multiple treatment-related complications or "late effects" including insulin resistance metabolic syndrome and diabetes mellitus. Abdominal and total body irradiation have been implicated as key mediators of this process but the precise pathways by which they lead to metabolic derangement are poorly understood. Optimal methods for early detection also remain unknown. Recent evidence has suggested that abnormalities of adipose tissue or fat may play an important role in the pathogenesis of metabolic complications in childhood cancer survivors. The current project seeks to assess whether adipose tissue exposed to radiation demonstrates molecular and morphological changes when compared to adipose tissue that has never been exposed to radiation.
Condition
- Childhood cancer
Eligibility
- Eligible Ages
- Between 18 and 49
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Study Design
- Phase
- Study Type
- Observational
More Details
- Status
- Recruiting
- Sponsor
- Rockefeller University