Purpose

Due to advances in multimodality therapy 5-year survival rates for childhood cancer now exceed 80%. Survivors however face an increased lifelong risk of multiple treatment-related complications or "late effects" including insulin resistance metabolic syndrome and diabetes mellitus. Abdominal and total body irradiation have been implicated as key mediators of this process but the precise pathways by which they lead to metabolic derangement are poorly understood. Optimal methods for early detection also remain unknown. Recent evidence has suggested that abnormalities of adipose tissue or fat may play an important role in the pathogenesis of metabolic complications in childhood cancer survivors. The current project seeks to assess whether adipose tissue exposed to radiation demonstrates molecular and morphological changes when compared to adipose tissue that has never been exposed to radiation.

Condition

Eligibility

Eligible Ages
Between 18 and 49
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Study Design

Phase
Study Type
Observational

More Details

Status
Recruiting
Sponsor
Rockefeller University

Study Contact

Recruitment Office
8007822737
rucares@rockefeller.edu

Notice

Study information shown on this site is derived from this institution's local clinical trials team. The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.