Purpose

Studies of genetic epidemiology have demonstrated that there exists a heritable contribution to individual variability in vulnerability to specific addictions. The overall goal of this project is to determine which variants of specific genes affect vulnerability to specific addictions. Our primary focus is on opiate addiction but addiction to other drugs and alcohol is also under study. Study subjects are thoroughly characterized using several structured and semi-structured instruments. We use both case-control and family-genetic approaches. Hypothesis driven selection of genes for study is used as well as positional methods using a variety of genetic markers to identify additional genes and gene variants contributing to addiction vulnerability.

Condition

Eligibility

Eligible Ages
Between 16 and 70
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Men and women of any race or ethnicity between the ages of 16 and 70 with and without previous or continuing histories of substance abuse or addiction to drugs including opiates cocaine and other psychostimulants alcohol cannabis sedatives hypnotics tranquilizers hallucinogens or inhalants

Exclusion Criteria

  • Persons with schizophrenia or other major psychotic mental illnesses
  • Individuals outside of the age range (16-70 yr)

Study Design

Phase
Study Type
Observational

More Details

Status
Recruiting
Sponsor
Rockefeller University

Study Contact

Recruitment Office
8007822737
rucares@rockefeller.edu

Notice

Study information shown on this site is derived from this institution's local clinical trials team. The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.