Human Genetic Correlates of the Addictive Diseases
Purpose
Studies of genetic epidemiology have demonstrated that there exists a heritable contribution to individual variability in vulnerability to specific addictions. The overall goal of this project is to determine which variants of specific genes affect vulnerability to specific addictions. Our primary focus is on opiate addiction but addiction to other drugs and alcohol is also under study. Study subjects are thoroughly characterized using several structured and semi-structured instruments. We use both case-control and family-genetic approaches. Hypothesis driven selection of genes for study is used as well as positional methods using a variety of genetic markers to identify additional genes and gene variants contributing to addiction vulnerability.
Condition
- Addictive diseases
Eligibility
- Eligible Ages
- Between 16 and 70
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Men and women of any race or ethnicity between the ages of 16 and 70 with and without previous or continuing histories of substance abuse or addiction to drugs including opiates cocaine and other psychostimulants alcohol cannabis sedatives hypnotics tranquilizers hallucinogens or inhalants
Exclusion Criteria
- Persons with schizophrenia or other major psychotic mental illnesses
- Individuals outside of the age range (16-70 yr)
Study Design
- Phase
- Study Type
- Observational
More Details
- Status
- Recruiting
- Sponsor
- Rockefeller University