Purpose

Multiple sclerosis (MS) is a disease of the brain in which blood vessels and the fatty tissue that insulates nerve cells myelin are damaged. How the brain tissues are damaged remains unknown. We have identified a toxin that is produced by the intestinal bacterium Clostridium perfringens as a possible cause of MS. This bacterial toxin named epsilon toxin specifically damages brain blood vessels and brain myelin. Additionally we have found that epsilon toxin damages immune cells in the blood called T cells. In this study we wish to collect blood from MS patients who are currently experiencing symptoms. We will test these blood samples for the presence of epsilon toxin. Damage to T cells by epsilon toxin also causes indirect damage to neighboring red blood cells the cells that carry oxygen in the blood. We have found that copper and iron released from toxin exposed T cells causes red blood cells to swell and breakdown more easily than normal. For these reasons we also wish to determine the mechanism by which copper and iron release is triggered by T cell toxin exposure.

Condition

Eligibility

Eligible Ages
Between 18 and 100
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • male or female at least 18 years of age

Exclusion Criteria

  • dementia
  • self-reported chronic infectious disease
  • self-reported autoimmune disorders (such as but not limited to Lupus Scleroderma Type one diabetes Graves disease Psoriasis Crohn's disease and Rheumatoid arthritis)
  • any disease that alters the size of RBCs
  • self-reported neurological disease
  • B12 deficiency
  • alcoholism
  • folate deficiency
  • hypothyroidism
  • myeloplastic disorders (bone marrow failure)
  • hereditary spherocytosis
  • self-reported hematologic disease
  • any liver disease including nonalcoholic fatty liver disease known as NASH (nonalcoholic steatohepatitis)

Study Design

Phase
Study Type
Observational

More Details

Status
Recruiting
Sponsor
Rockefeller University

Study Contact

Recruitment Office
8007822737
rucares@rockefeller.edu

Notice

Study information shown on this site is derived from this institution's local clinical trials team. The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.