Human Genetic Correlates of the Addictive Diseases
Purpose
class="MsoNormal" style="text-indent:-0.25in;mso-list:l0 level1 lfo1;tab-stops:0in list .5in left 1.0in 1.5in 2.0in 2.5in 3.0in 3.5in 4.0in 4.5in 5.0in 5.5in 6.0in 6.5in;margin:0in 0in 0pt 0.5in;"><span style="font-family: Verdana Geneva sans-serif; font-size: 12px;"> Studies of genetic epidemiology have demonstrated that there exists a heritable contribution to individual variability in vulnerability to specific addictions. The overall goal of this project is to determine which variants of specific genes affect vulnerability to specific addictions. Our primary focus is on opiate addiction but addiction to other drugs and alcohol is also under study. Study subjects are thoroughly characterized using several structured and semi-structured instruments. We use both case-control and family-genetic approaches. Hypothesis driven selection of genes for study is used as well as positional methods using a variety of genetic markers to identify additional genes and gene variants contributing to addiction vulnerability.
Condition
- Addictive diseases
Eligibility
- Eligible Ages
- Between 16 and 70
- Eligible Genders
- 1
- Accepts Healthy Volunteers
- Yes
Study Design
- Phase
- Study Type
- Observational
More Details
- Status
- Recruiting
- Sponsor
- Rockefeller University