Characterizing the interaction between fibrin platelets and A? using an ex vivo clotting assay.
Purpose
The Alzheimer's disease pathological peptide A? can affect blood clotting but a mechanism for this action is not fully understood. To investigate this effect further we will use an test tube assay for clotting to determine how A? interacts with both fibrin and platelets in human blood. Using this assay we have already observed that A? binds to a collagen surface when fibrin is present and that platelets bind to A? forming clots that are more stable than those formed in the absence of A?. We will use this clotting assay with real time imaging to explore how different structural forms and known mutants of A? alter clot formation and structure through their interaction with platelets and fibrin.
Condition
- Healthy volunteers
Eligibility
- Eligible Ages
- Between 45 and 75
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Study Design
- Phase
- Study Type
- Observational
More Details
- Status
- Recruiting
- Sponsor
- Rockefeller University