Characterizing the interaction between fibrin platelets and Aß using an ex vivo clotting assay.
Purpose
The Alzheimer's disease pathological peptide Aß can affect blood clotting but a mechanism for this action is not fully understood. To investigate this effect further we will use an test tube assay for clotting to determine how Aß interacts with both fibrin and platelets in human blood. Using this assay we have already observed that Aß binds to a collagen surface when fibrin is present and that platelets bind to Aß forming clots that are more stable than those formed in the absence of Aß. We will use this clotting assay with real time imaging to explore how different structural forms and known mutants of Aß alter clot formation and structure through their interaction with platelets and fibrin.
Condition
- Healthy volunteers
Eligibility
- Eligible Ages
- Between 18 and 80
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Study Design
- Phase
- Study Type
- Observational
More Details
- Status
- Recruiting
- Sponsor
- Rockefeller University